Gut Microbiota-Derived Short-Chain Fatty Acids, T Cells, and Inflammation
Immune Network
;
: 277-288, 2014.
Artigo
em Inglês
| WPRIM
| ID: wpr-116967
ABSTRACT
T cells are central players in the regulation of adaptive immunity and immune tolerance. In the periphery, T cell differentiation for maturation and effector function is regulated by a number of factors. Various factors such as antigens, co-stimulation signals, and cytokines regulate T cell differentiation into functionally specialized effector and regulatory T cells. Other factors such as nutrients, micronutrients, nuclear hormones and microbial products provide important environmental cues for T cell differentiation. A mounting body of evidence indicates that the microbial metabolites short-chain fatty acids (SCFAs) have profound effects on T cells and directly and indirectly regulate their differentiation. We review the current status of our understanding of SCFA functions in regulation of peripheral T cell activity and discuss their impact on tissue inflammation.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Linfócitos T
/
Diferenciação Celular
/
Citocinas
/
Interleucina-10
/
Linfócitos T Reguladores
/
Colite
/
Micronutrientes
/
Sinais (Psicologia)
/
Ácidos Graxos Voláteis
/
Imunidade Adaptativa
Idioma:
Inglês
Revista:
Immune Network
Ano de publicação:
2014
Tipo de documento:
Artigo
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