The Effects of Ethanol and Acetaldehyde on Corpus Cavernosal Smooth Muscle of the Rabbit / 대한남성과학회지
Korean Journal of Andrology
;
: 170-176, 2009.
Artigo
em Inglês
| WPRIM
| ID: wpr-117317
ABSTRACT
PURPOSE:
This study is to assess the pharmacologic effects of ethanol and its metabolite, acetaldehyde on potassium channels of the corpus cavernosal smooth muscle of the rabbit. MATERIALS ANDMETHODS:
Cavernosal strips from New Zealand white rabbits were harvested and pharmacophysiologic organ bath studies were executed. In equilibrium state after incubation, zaprinast (PDE5 inhibitor) induced relaxations were monitored in strips precontracted with phenylephrine (PE, 10(-4)M). The inhibitory effects of ethanol and acetaldehyde (2, 20, 40, 80 mmol) on zaprinast-induced relaxations were recorded. Pinacidil (K(ATP) channel opener) and phloretin (BK channel opener) were tested to reverse the inhibitory effects of ethanol and acetaldehyde on zaprinast-induced relaxations.RESULTS:
Both ethanol and acetaldehyde inhibited the zaprinast-induced relaxations in a dosedependent manner (p<0.05). Both pinacidil and phloretin abolished the inhibition by both ethanol and acetaldehyde (p<0.05). Ethanol and acetaldehyde inhibits cavernosal relaxation, possibly through BK channels and K(ATP) channels.CONCLUSIONS:
These results suggest that ethanol and its metabolite may affect the corpus cavernosal smooth muscle directly and lead to consequent erectile dysfunction. Furthermolecular and electrophysiological studies will help reveal the underlying mechanisms to which this process occurs.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Pênis
/
Fenilefrina
/
Floretina
/
Purinonas
/
Relaxamento
/
Banhos
/
Canais de Potássio
/
Pinacidil
/
Etanol
/
Canais de Potássio Ativados por Cálcio de Condutância Alta
Limite:
Animais
Idioma:
Inglês
Revista:
Korean Journal of Andrology
Ano de publicação:
2009
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS