Treatment of Hemangiopericytoma-Associated Hypoglycemia with Glucocorticoid Therapy / 영남의대학술지
Yeungnam University Journal of Medicine
;
: 77-83, 2011.
Artigo
em Coreano
| WPRIM
| ID: wpr-117519
ABSTRACT
Non-islet cell tumor-induced hypoglycemia (NICTH) is associated with mesenchymal tumor types, including hemangiopericytoma, fibrosarcoma, mesothelioma, and neurofibroma, as well as carcinoma of the liver, adrenal glands, and kidneys. Non-islet cell tumors induce hypoglycemia by overproducing an abnormal form of insulin-like growth factor II (IGF II). Complete removal of the tumor or reduction of the tumor mass is a successful therapeutic strategy in cases of NICTH. However, if the tumor re-grows, curative resection is nearly impossible, and hypoglycemia occurs repeatedly. Glucocorticoids are effective in terms of long-term relief from hypoglycemia through promotion of gluconeogenesis in the liver, tumor suppression, production of 'big'-IGF-II, and correction of the attendant biochemical abnormalities involving the growth hormone (GH)-IGF axis. We found that administration of corticosteroid therapy to a patient suffering from NICTH resulted in improvement of hypoglycemia associated symptoms.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Estresse Psicológico
/
Vértebra Cervical Áxis
/
Fator de Crescimento Insulin-Like II
/
Prednisolona
/
Hormônio do Crescimento
/
Glândulas Suprarrenais
/
Fibrossarcoma
/
Glucocorticoides
/
Gluconeogênese
/
Hemangiopericitoma
Limite:
Humanos
Idioma:
Coreano
Revista:
Yeungnam University Journal of Medicine
Ano de publicação:
2011
Tipo de documento:
Artigo
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