Beta agonist regulation of sodium transport in fetal lung epithelium: roles of cell volume, cytosolic chloride and protein tyrosine kinase
Journal of Korean Medical Science
;
: S42-S43, 2000.
Artigo
em Inglês
| WPRIM
| ID: wpr-117526
ABSTRACT
1) A beta agonist stimulated Na+ transport and decreased the intracellular Cl concentration ([Cl]c) associated with cell shrinkage via an increase in cytosolic cAMP level by activating adenylate cyclase in rat fetal distal lung epithelial (FDLE) cells. 2) Lowering [Cl-]c activated a 28-pS nonselective cation (NSC) channel by elongating the open time of the channel. 3) cAMP signals were converted to a protein tyrosine kinase (PTK)-mediated signal. 4) The PTK-mediated signal was involved in the cAMP-stimulated Na+ transport in rat FDLE cells.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Sódio
/
Transporte Biológico
/
Colforsina
/
Proteínas Tirosina Quinases
/
Cloretos
/
Ratos Wistar
/
AMP Cíclico
/
Agonistas Adrenérgicos beta
/
Tirfostinas
/
Mucosa Respiratória
Limite:
Animais
/
Gravidez
Idioma:
Inglês
Revista:
Journal of Korean Medical Science
Ano de publicação:
2000
Tipo de documento:
Artigo
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