Effects of Smoking on Patients with Parkinson's Disease
Journal of the Korean Neurological Association
;
: 394-401, 2000.
Artigo
em Coreano
| WPRIM
| ID: wpr-117540
ABSTRACT
BACKGROUND:
The cause of idiopathic Parkinson's disease (IPD) is unknown. Recent studies suggest that IPD occurs less frequently in smokers than in non-smokers, but remains a controversial topic. We performed a case-control study to investigate the relationship between IPD and smoking in Korea.METHODS:
The smoking histories of 624 IPD patients were compared with 622 age- and sex-matched control subjects at the Asan Medical Center. Detailed informa-tion on smoking behavior was identified from a questionnaire and self report. A conditional logistic regression was used to calculate the odds ratio (OR) and control for potential confounds.RESULTS:
With "never-smokers" as the refer-ence category, there was an inverse association between past-smokers and IPD (OR 0.617, p=0.029), and a stronger inverse association of IPD with current-smokers (OR 0.389, p<0.001). When smokers were stratified by the interval "since quitting", there was an inverse association between those who stopped smoking more than 10 years ago and IPD (OR 0.753, p=0.31), and a greater inverse relationship with those who stopped smoking 1 to 10 years (OR 0.489, p=0.017). A significant trend of decreased risk of IPD with pack-years of smoking was detected.CONCLUSIONS:
This study suggests that IPD occurs less often in smokers than in non-smokers. The inverse dose-response relationship between smoking and IPD provides indirect evidence that smoking is biologically protective.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Doença de Parkinson
/
Fumaça
/
Fumar
/
Estudos de Casos e Controles
/
Modelos Logísticos
/
Razão de Chances
/
Inquéritos e Questionários
/
Autorrelato
/
Coreia (Geográfico)
Tipo de estudo:
Estudo de etiologia
/
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Limite:
Humanos
País/Região como assunto:
Ásia
Idioma:
Coreano
Revista:
Journal of the Korean Neurological Association
Ano de publicação:
2000
Tipo de documento:
Artigo
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