Activated Protein C Resistance and Factor V Leiden Mutation in Patients with Arterial Ischemic Stroke
Journal of the Korean Neurological Association
;
: 390-393, 2000.
Artigo
em Coreano
| WPRIM
| ID: wpr-117541
ABSTRACT
BACKGROUND:
In the western hemisphere, resistance to activated protein C (APCR) is the most common risk factor for venous thromboembolic disease. A one-point mutation in the coagulation factor V that renders it APCR is found in more than 90% of patients with APC-resistant venous thrombosis. In Hispanic and Caucasian patients with arterial ischemic stroke, the prevalence of APC-R is approximately 10%. To determine the prevalence of APC resistance and its causative factor V mutation (Arg 506 Gln) in Koreans, we screened a group of Korean ischemic stroke patients.METHODS:
We evaluated 60 Korean patients with arterial ischemic stroke diagnosed by either magnetic resonance neu-roimaging, conventional angiogram, or both, after 2 weeks of symptom onset. The mean age of the subjects was 59.2 years (13-82 years). APC resistance was expressed as a ratio of the activated partial thromboplastin time (aPTT) with and without adding APC to the subject's plasma. The presence of the factor V Leiden (Arg 506 Gln) mutation was determined by a direct polymerase chain reaction-based assay on peripheral blood leukocytes.RESULTS:
Only one patient (n=1/60, 1.6%) had APC resistance and none were found to have the factor V Leiden (Arg 506 Gln) mutation.CONCLUSIONS:
APCR and the factor V Leiden mutation do not seem to be a significant genetic risk factor for arterial ischemic stroke in Koreans.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Tempo de Tromboplastina Parcial
/
Plasma
/
Fator V
/
Proteína C
/
Hispânico ou Latino
/
Prevalência
/
Fatores de Risco
/
Trombose Venosa
/
Resistência à Proteína C Ativada
/
Acidente Vascular Cerebral
Tipo de estudo:
Estudo de etiologia
/
Estudo de prevalência
/
Fatores de risco
Limite:
Humanos
Idioma:
Coreano
Revista:
Journal of the Korean Neurological Association
Ano de publicação:
2000
Tipo de documento:
Artigo
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