Malignant Gastrointestinal Stromal Tumor of the Ampulla of Vater: A Case Report / 대한소화기학회지
The Korean Journal of Gastroenterology
;
: 66-70, 2004.
Artigo
em Inglês
| WPRIM
| ID: wpr-117622
ABSTRACT
GIST is a rare neoplasm, the majority of GISTs are located in the stomach and small intestine. Most GISTs are diagnosed histopathologically after resection because of submucosal location. A 37-year-old female patient presented with a 2-weeks history of generalized weakness, nausea accompanied by intermittent passage of black, tarry stools. Esophagogastroduodenoscopy and ERCP showed a large round mass measuring 5 cm in diameter in the ampulla of Vater with ulcer crack. Endoscopic multiple biopsies from the mass including ulcer base were taken. Light microscopic findings showed spindle-shaped and epitheloid tumor cells having high cellularity and frequent mitotic figures. On immunohistochemical stainings, the tumor cells were positive for CD34 and smooth muscle actin. Based on these preoperative findings, a diagnosis of malignant GIST of the ampulla of Vater was made probably. After operation, immunohistochemical studies revealed positive reaction for c-kit and vimentin, as well as focally reactive for CD34 and smooth muscle actin. We report a case of GIST in the ampulla of Vater presenting with melena that was diagnosed preoperatively and postoperatively.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Ampola Hepatopancreática
/
Neoplasias do Ducto Colédoco
/
Tumores do Estroma Gastrointestinal
Limite:
Adulto
/
Feminino
/
Humanos
Idioma:
Inglês
Revista:
The Korean Journal of Gastroenterology
Ano de publicação:
2004
Tipo de documento:
Artigo
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