Nucleoside Diphosphate Kinase from Microorganisms
Journal of Bacteriology and Virology
; : 92-98, 2013.
Article
em Ko
| WPRIM
| ID: wpr-117662
Biblioteca responsável:
WPRO
ABSTRACT
Nucleoside diphosphate kinase (Ndk) is ubiquitous and highly conserved multifunctional key enzyme in nucleotide metabolism. It generates nucleoside triphosphates (NTPs) by transfer of gamma-phosphates from nucleoside triphosphates such as ATP or GTP to nucleoside diphosphate. The formation of an autophosphorylated enzyme intermediate is involved in that mechanism. The phosphate is usually supplied by ATP and Ndk activity in different subcellular compartments. Ndk may regulate the crucial balance between ATP and GTP or other nucleoside triphosphates. Ndk is playing an important role in bacterial pathogenesis and emerging evidences recognize multiple roles of Ndk in host-microbe interaction. Here, I review some examples of the role of Ndk in intra- and extracellular microorganism.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Trifosfato de Adenosina
/
Núcleosídeo-Difosfato Quinase
/
Guanosina Trifosfato
Idioma:
Ko
Revista:
Journal of Bacteriology and Virology
Ano de publicação:
2013
Tipo de documento:
Article