Treatment and outcomes: medical and surgical treatment for intestinal Behçet's disease
Intestinal Research
;
: 318-327, 2017.
Artigo
em Inglês
| WPRIM
| ID: wpr-117804
ABSTRACT
Behçet's disease (BD) is a chronic relapsing disease involving multiple organ systems. BD is characterized clinically by oral and genital aphthae, cutaneous lesions, and ophthalmological, neurological, and/or gastrointestinal manifestations. It is widely recognized that the presence of intestinal lesions may be a poor prognostic factor in intestinal BD, increasing the risk of surgery and decreasing the quality of life. Despite this, the management of intestinal BD has not been standardized. Empirical therapies including 5-aminosalicylic acid and corticosteroids have been used anecdotally to treat intestinal BD, but recent studies have provided evidence for the efficacy of anti-tumor necrosis factor α monoclonal antibodies. The development of agents targeting tumor necrosis factor α continues, it seems likely that they will change the therapeutic strategy and clinical outcomes of intestinal BD and inflammatory bowel disease. Monitoring disease activity such as endoscopic evaluation will become more important to obtain better outcomes. Here, we review current and future perspectives in the treatment and outcomes of intestinal BD.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Qualidade de Vida
/
Estomatite Aftosa
/
Doenças Inflamatórias Intestinais
/
Fator de Necrose Tumoral alfa
/
Corticosteroides
/
Mesalamina
/
Anticorpos Monoclonais
/
Necrose
Tipo de estudo:
Estudo prognóstico
Idioma:
Inglês
Revista:
Intestinal Research
Ano de publicação:
2017
Tipo de documento:
Artigo
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