Development of Monoclonal Antibodies Recognizing Human Peripheral Blood T Lymphocytes Cytoplasmic Proteins Induced upon Activation / 대한면역학회지
Korean Journal of Immunology
;
: 145-156, 1997.
Artigo
em Coreano
| WPRIM
| ID: wpr-117925
ABSTRACT
Antigen-specific T cell activation requires interaction of the T cell with specialized antigen-presenting cells. Signaling through the TCR is necessary but not sufficient to induce antigen-specific T cell activation and cytokine secretion. This first signal, termed signal 1, is both antigen-specific and MHC-restricted. Signal 2, which is neither antigen-specific nor MHC-restricted, is necessary to induce cytokine secretion, cellular proliferation, and effector function. Recently immunological studies in T cell activation area are mainly focused on biological and molecular biological characterization of TCR/CD3 complex and accessary molecules providing costimulatory signal (signal 2). If signal 2 is not delivered, T cell enter a state of long term un-responsiveness to specific antigen-termed anergy. Monoclonal antibody technique has been especially involved in recognizing novel inducible cell surface antigens on T cell activation. This study was aimed to develop monoclonal antibodies recognizing novel cytoplasmic proteins present in activated T cells. We make 6 monoclones involved in changing pattern of T cell activated cytoplasmic proteins. Using these 6 monoclonal antibodies analyze to find novel molecules involved in T cell activation associated response, apoptosis, and/or heat shock response of the T cells in early T cell activation.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Linfócitos T
/
Apoptose
/
Resposta ao Choque Térmico
/
Citoplasma
/
Proliferação de Células
/
Proteínas de Choque Térmico
/
Anticorpos Monoclonais
/
Células Apresentadoras de Antígenos
/
Antígenos de Superfície
Limite:
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Immunology
Ano de publicação:
1997
Tipo de documento:
Artigo
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