Inhibition of Cyclooxygenase-2 (Cox-2) Expression by Genistein in Breast Cancer Cell-line / 한국유방암학회지
Journal of Korean Breast Cancer Society
;
: 277-282, 2003.
Artigo
em Coreano
| WPRIM
| ID: wpr-118846
ABSTRACT
PURPOSE:
The isoflavones in soy are likely to contribute to the historically low incidence of breast cancer among Asian women that consume traditional diets. A possible role of isoflavones in controlling the expression of cyclooxygenase-2 (Cox-2) has not previously been explored. In this study, the ability of the isoflavone, genistein, to regulate the expression of Cox-2 in breast cancer cells was evaluated.METHODS:
The effects of genistein and NS-398, a Cox-2 inhibitor, were examined on the expression of Cox-2 at the mRNA level using the MDA-MB 231, and MCF-7 breast cancer cell-lines.RESULTS:
In the MCF-7 cells, the Cox-2 mRNA could not be detected using RT-PCR. In the MDA-MB-231 cells, NS-398 and genistein were found to inhibit the Cox-2 mRNA expressions by 50 and 35~40%, respectively.CONCLUSION:
These studies suggest that dietary isoflavonoids may contribute to the prevention or inhibition of breast cancer by inhibiting the Cox-2 expression.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Mama
/
Neoplasias da Mama
/
RNA Mensageiro
/
Incidência
/
Genisteína
/
Povo Asiático
/
Dieta
/
Ciclo-Oxigenase 2
/
Células MCF-7
/
Isoflavonas
Tipo de estudo:
Estudo de incidência
/
Estudo prognóstico
Limite:
Feminino
/
Humanos
Idioma:
Coreano
Revista:
Journal of Korean Breast Cancer Society
Ano de publicação:
2003
Tipo de documento:
Artigo
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