Glycopeptide Antibiotics: Structure and Mechanisms of Action
Journal of Bacteriology and Virology
;
: 67-78, 2015.
Artigo
em Inglês
| WPRIM
| ID: wpr-119552
ABSTRACT
Glycopeptides of the clinically important antibiotic drugs are glycosylated cyclic or polycyclic nonribosomal peptides. Glycopeptides such as vancomycin and teicoplanin are often used for the treatment of gram-positive bacteria in patients. The increased incidence of drug resistance and inadequacy of these therapeutics against gram-positive bacterial infections would be the formation and clinical development of more variable second generation of glycopeptide antibiotics semisynthetic lipoglycopeptide analogs such as telavancin, dalbavancin, and oritavancin with improved activity and better pharmacokinetic properties. In this review, we describe the development of and bacterial resistance to vancomycin, teicoplanin, and semisynthetic glycopeptides (teicoplanin, dalbavancin, and oritavancin). The clinical influence of resistance to glycopeptides, particularly vancomycin, are also discussed.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Peptídeos
/
Resistência a Medicamentos
/
Glicopeptídeos
/
Vancomicina
/
Incidência
/
Infecções por Bactérias Gram-Positivas
/
Teicoplanina
/
Bactérias Gram-Positivas
/
Antibacterianos
Tipo de estudo:
Estudo de incidência
/
Estudo prognóstico
Limite:
Humanos
Idioma:
Inglês
Revista:
Journal of Bacteriology and Virology
Ano de publicação:
2015
Tipo de documento:
Artigo
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