Implication of Egr-1 in trifluoperazine-induced growth inhibition in human U87MG glioma cells
Exp. mol. med
; Exp. mol. med;: 380-386, 2004.
Article
em En
| WPRIM
| ID: wpr-119638
Biblioteca responsável:
WPRO
ABSTRACT
The early growth response gene-1 (Egr-1) is a tumor suppressor which plays an important role in cell growth, differentiation and apoptosis. Egr-1 has been shown to be down-regulated in many types of tumor tissues. Trifluoperazine (TFP), a phenothiazine class of antipsychotics, restored serum-induced Egr-1 expression in several cancer cell lines. We investigated the effect of Egr-1 expression on the TFP-induced inhibition of cell growth. Ectopic expression of Egr-1 enhanced the TFP-induced antiproliferative activity and downregulated cyclin D1 level in U87MG glioma cells. Our results suggest that antipsychotics TFP exhibits antiproliferative activity through up-regulation of Egr-1.
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Texto completo:
1
Índice:
WPRIM
Assunto principal:
Fatores de Transcrição
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Trifluoperazina
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Células Tumorais Cultivadas
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Expressão Gênica
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Ciclo Celular
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Regiões Promotoras Genéticas
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Proteínas Imediatamente Precoces
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Ciclina D1
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Proliferação de Células
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Proteínas de Ligação a DNA
Limite:
Humans
Idioma:
En
Revista:
Exp. mol. med
Ano de publicação:
2004
Tipo de documento:
Article