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Expression of Lectin like Oxidized Low Density Lipoprotein Receptor-1 in the Spontaneous Hypertensive Rat with High Cholesterol Diet
Journal of the Korean Society of Hypertension ; : 57-64, 2011.
Artigo em Coreano | WPRIM | ID: wpr-119730
ABSTRACT

BACKGROUND:

Lectin-like, oxidized, low-density lipoprotein receptorreceptors (LOX-1) recognizes recognize vascular oxidized low-density lipoprotein (LDL), which may play an important role in the pathogenesis of atherosclerosis. We investigated the expressions expression of LOX-1 and redox-regulating thyoredoxinthioredoxin systems in a hypertension and hypercholesterolemia rat model.

METHODS:

Spontaneously hypertensive rats (SHR) and Wistar-Kyoto rat (WKY) rats were fed with a normal cholesterol diet (NC) and a high cholesterol diet (HC) for 4 weeks. Plasma LDL cholesterol levels and blood pressure were measured at 1 and 4 weeks. Histological changes of atherosclerosis in the vessel was evaluated by hematoxylin and eosin staining and immunocytochemistry. The expressions expression of LOX-1 and thyoredoixnthioredoxin were measured by Western western blot analysis.

RESULTS:

In the SHR groupsgroup, blood pressure after 4 weeks was significantly higher than initial levels. LDL-cholesterol levels in the SHR-HC group were increased at 4 weeks (15.3 +/- 2.6 mg/dL vs. 20.2 +/- 2.6 mg/dL, p < 0.01) compared with the SHR-NC group. In oxyblot analysis, the degree of oxidative stress of in the SHR-HC group was significantly higher than in the SHR-NC group (p < 0.05). The expressions expression of LOX-1 and Trx were was significantly increased in the SHR-HC group compared with the SHR-NC group (p < 0.05) on western blot analysis. Focal overexpressions overexpression of LOX-1 were was observed at the intima layer of the thoracic aorta, and was which wereonly observed in the SHR-HC group.

CONCLUSIONS:

The expressions expression of LOX-1 and oxidative stress were was significantly increased in the "hypertension with hypercholesterol" rat model. These findings suggested suggest that LOX-1 and redox systems may play a certain role in development and progression of atherosclerosis.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Aorta Torácica / Oxirredução / Plasma / Ratos Endogâmicos SHR / Pressão Sanguínea / Imuno-Histoquímica / Western Blotting / Colesterol / Amarelo de Eosina-(YS) / Estresse Oxidativo Tipo de estudo: Estudo prognóstico Limite: Animais Idioma: Coreano Revista: Journal of the Korean Society of Hypertension Ano de publicação: 2011 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Aorta Torácica / Oxirredução / Plasma / Ratos Endogâmicos SHR / Pressão Sanguínea / Imuno-Histoquímica / Western Blotting / Colesterol / Amarelo de Eosina-(YS) / Estresse Oxidativo Tipo de estudo: Estudo prognóstico Limite: Animais Idioma: Coreano Revista: Journal of the Korean Society of Hypertension Ano de publicação: 2011 Tipo de documento: Artigo