The Age Impact on Serum Total and Allergen-Specific IgE
Allergy, Asthma & Immunology Research
; : 170-174, 2013.
Article
em En
| WPRIM
| ID: wpr-120068
Biblioteca responsável:
WPRO
ABSTRACT
Aging is accompanied by a progressive decline in almost all functions of the immune system. To investigate a possible impact of age on IgE production, this study evaluated total and allergen-specific serum IgE levels in a large cohort of allergic patients. This study included 6,370 allergic patients (2,961 females, 3,409 males; mean age, 21.7 years; age range, 0-96 years). Total and allergen-specific serum IgE levels were measured by immunoenzymatic assay. The analysis of variance showed a significant difference (P<0.0001) in the mean value of total IgE among the different age groups of patients. Moreover, specific IgE levels for all allergens examined differed significantly among the age groups of patients (P<0.0001), with a specific trend pattern for each allergen. Total IgE increased with age, but allergen-specific IgE levels significantly decreased with age, with a trend specific for each allergen tested.
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Texto completo:
1
Índice:
WPRIM
Assunto principal:
Envelhecimento
/
Imunoglobulina E
/
Alérgenos
/
Estudos de Coortes
/
Hipersensibilidade
/
Sistema Imunitário
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Female
/
Humans
Idioma:
En
Revista:
Allergy, Asthma & Immunology Research
Ano de publicação:
2013
Tipo de documento:
Article