Application of CRISPR/Cas9 in Treating Hepatitis B Virus
Journal of Liver Cancer
;
: 111-116, 2017.
Artigo
em Inglês
| WPRIM
| ID: wpr-120522
ABSTRACT
The advent of oral antiviral agents has revolutionized hepatitis B treatment. It has led to decreased incidence and mortality related to hepatocellular carcinoma. However, although nucleos(t)ide analogs (NA) are fast and potent in inhibiting hepatitis B virus (HBV) polymerase and reverse transcriptase activity, complete cure of the virus is not possible. The complete eradication of HBV requires the covalently-closed-circular DNA (cccDNA) to be eliminated. Novel gene editing methods, such as zing finger nucleases, transcription activator-like effector nucleases, and the clustered regularly interspaced short palindromic repeats/Cas9 (CRISPR/Cas9) system, designed to target specific DNA sequences has great potential for therapeutic application. Among these, the CRISPR/Cas9 system may be the most feasible approach to eradicate HBV cccDNA. Further studies are needed to develop a more efficient and safer method of delivery using the CRISPR/Cas9 system to achieve complete cure of chronic hepatitis B.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Antivirais
/
DNA
/
DNA Circular
/
Sequência de Bases
/
Vírus da Hepatite B
/
Incidência
/
Mortalidade
/
DNA Polimerase Dirigida por RNA
/
Carcinoma Hepatocelular
/
Hepatite B Crônica
Tipo de estudo:
Estudo de incidência
/
Estudo prognóstico
Idioma:
Inglês
Revista:
Journal of Liver Cancer
Ano de publicação:
2017
Tipo de documento:
Artigo
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