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Contraction and Relaxation Responses of Isolated Rabbit Seminal Vesicle to Selective beta Subtypes-adrenoceptor Agonists and Antagonists / 대한비뇨기과학회지
Korean Journal of Urology ; : 726-731, 2004.
Artigo em Coreano | WPRIM | ID: wpr-120838
ABSTRACT

PURPOSE:

This study was aimed at investigating the role of betaadrenoceptor subtypes in mediating the relaxation and contraction of seminal vesicles in rabbits. MATERIALS AND

METHODS:

Relaxation or contractile responses of epithelium- removed muscle strips of a rabbit seminal vesicle, which were precontracted with 10-5M norepinephrine, to selective betasubtypes-adrenoceptor agonists were observed in an organ bath. The contractile responses induced by isoproterenol were also observed after application of selective antagonists.

RESULTS:

Isoproterenol showed a concentration-dependent contractile response, but the contractility was weaker than those with phenylephrine and norepinephrine. The betaselective-agonists(xamoterol for beta, clenbuterol for beta and BRL37344 for beta) alone evoked neither contraction nor relaxation. However, the beta- and beta-agonists inhibited the contraction of the precontracted strips with 10-5M norepinephrine, while the beta-agonist enhanced the contraction. The pretreatment with a beta-antagonist(ICI118551) reduced the tension of the strips developed by 10-4M isoproterenol, but the beta-(atenolol) and beta-(SR59230A) antagonists showed no changes in the response.

CONCLUSIONS:

beta- and beta-adrenoceptors seem to mediate the relaxation of the seminal vesicle, while the beta-adrenoceptor may have a supplementary role in contraction.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Fenilefrina / Relaxamento / Glândulas Seminais / Banhos / Norepinefrina / Negociação / Clembuterol / Isoproterenol Limite: Animais Idioma: Coreano Revista: Korean Journal of Urology Ano de publicação: 2004 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Fenilefrina / Relaxamento / Glândulas Seminais / Banhos / Norepinefrina / Negociação / Clembuterol / Isoproterenol Limite: Animais Idioma: Coreano Revista: Korean Journal of Urology Ano de publicação: 2004 Tipo de documento: Artigo