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Effects of Some Local Anesthetics on Ca++ Binding to Lipid-Extracted RBC Membrane, Egg Albumin Film and Filter Paper
Yonsei Medical Journal ; : 1-9, 1973.
Artigo em Inglês | WPRIM | ID: wpr-12096
ABSTRACT
Local anesthetics at a concentration of 10 mM(procaine and lidocaine) were found to inhibit competitively Ca++ binding to lipidextracted RBC membrane, and also to egg albumin film fixed on cover glasses or impregnated into Whatman filter paper (No. 1). A competitive inhibition by local anesthetics was also found in Ca++ binding to Whatman filter paper which had been pretreated with organic solvents to extract possible contaminated lipids. Therefore, it is suggested that the local anesthetics inhibit Ca++ binding not only to phospholipids but to some macromolecules such as membrane proteins, egg albumin film and filter paper.
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Procaína / Permeabilidade da Membrana Celular / Ovalbumina / Cálcio / Eritrócitos / Filtração / Anestésicos Locais / Lidocaína Limite: Humanos Idioma: Inglês Revista: Yonsei Medical Journal Ano de publicação: 1973 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Procaína / Permeabilidade da Membrana Celular / Ovalbumina / Cálcio / Eritrócitos / Filtração / Anestésicos Locais / Lidocaína Limite: Humanos Idioma: Inglês Revista: Yonsei Medical Journal Ano de publicação: 1973 Tipo de documento: Artigo