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Time-course changes of hippocalcin expression in the mouse hippocampus following pilocarpine-induced status epilepticus
Journal of Veterinary Science ; : 137-144, 2016.
Artigo em Inglês | WPRIM | ID: wpr-121459
ABSTRACT
Hippocalcin participates in the maintenance of neuronal calcium homeostasis. In the present study, we examined the time-course changes of neuronal degeneration and hippocalcin protein level in the mouse hippocampus following pilocarpine-induced status epilepticus (SE). Marked neuronal degeneration was observed in the hippocampus after SE in a time-dependent manner, although neuronal degeneration differed according to the hippocampal subregions. Almost no hippocalcin immunoreactivity was detected in the pyramidal neurons of the cornu ammonis 1 (CA1) region from 6 h after SE. However, many pyramidal neurons in the CA2 region showed hippocalcin immunoreactivity until 24 h after SE. In the CA3 region, only a few hippocalcin immunoreactive cells were observed at 12 h after SE, and almost no hippocalcin immunoreactivity was observed in the pyramidal neurons from 24 h after SE. Hippocalcin immunoreactivity in the polymorphic cells of the dentate gyrus was markedly decreased from 6 h after SE. In addition, hippocalcin protein level in the hippocampus began to decrease from 6 h after SE, and was significantly decreased at 24 h and 48 h after pilocarpine-induced SE. These results indicate that marked reduction of hippocalcin level may be closely related to neuronal degeneration in the hippocampus following pilocarpine-induced SE.
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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Estado Epiléptico / Cálcio / Células Piramidais / Giro Denteado / Hipocalcina / Hipocampo / Homeostase / Neurônios Limite: Animais Idioma: Inglês Revista: Journal of Veterinary Science Ano de publicação: 2016 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Estado Epiléptico / Cálcio / Células Piramidais / Giro Denteado / Hipocalcina / Hipocampo / Homeostase / Neurônios Limite: Animais Idioma: Inglês Revista: Journal of Veterinary Science Ano de publicação: 2016 Tipo de documento: Artigo