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Impact of Slow Blood Filling via Collaterals on Infarct Growth: Comparison of Mismatch and Collateral Status / 대한뇌졸중학회지
Journal of Stroke ; : 88-96, 2017.
Artigo em Inglês | WPRIM | ID: wpr-121539
ABSTRACT
BACKGROUND AND

PURPOSE:

Perfusion-diffusion mismatch has been evaluated to determine whether the presence of a target mismatch helps to identify patients who respond favorably to recanalization therapies. We compared the impact on infarct growth of collateral status and the presence of a penumbra, using magnetic resonance perfusion (MRP) techniques.

METHODS:

Consecutive patients who were candidates for recanalization therapy and underwent serial diffusion-weighted imaging (DWI) and MRP were enrolled. A collateral flow map derived from MRP source data was generated by automatic post-processing. The impact of a target mismatch (Tmax>6 s/apparent diffusion coefficient (ADC) volume≥1.8, ADC volume10 s for ADC volume<100 mL) on infarct growth was compared with MR-based collateral grading on day 7 DWI, using multivariate linear regression analysis.

RESULTS:

Among 73 patients, 55 (75%) showed a target mismatch, whereas collaterals were poor in 14 (19.2%), intermediate in 36 (49.3%), and good in 23 (31.5%) patients. After adjusting for initial severity of stroke, early recanalization (P<0.001) and the MR-based collateral grading (P=0.001), but not the presence of a target mismatch, were independently associated with infarct growth. Even in patients with a target mismatch and successful recanalization, the degree of infarct growth depended on the collateral status. Perfusion status at later Tmax time points (beyond the arterial phase) was more closely correlated with collateral status.

CONCLUSIONS:

Patients with good collaterals show a favorable outcome in terms of infarct growth, regardless of the presence of a target mismatch pattern. The presence of slow blood filling predicts collateral status and infarct growth.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Perfusão / Imageamento por Ressonância Magnética / Modelos Lineares / Circulação Colateral / Acidente Vascular Cerebral / Difusão Tipo de estudo: Estudo prognóstico Limite: Humanos Idioma: Inglês Revista: Journal of Stroke Ano de publicação: 2017 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Perfusão / Imageamento por Ressonância Magnética / Modelos Lineares / Circulação Colateral / Acidente Vascular Cerebral / Difusão Tipo de estudo: Estudo prognóstico Limite: Humanos Idioma: Inglês Revista: Journal of Stroke Ano de publicação: 2017 Tipo de documento: Artigo