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Nail Changes in Patients with Alopecia Areata: Clinical Presentation and Associated Factors / 대한피부과학회지
Korean Journal of Dermatology ; : 538-543, 2016.
Artigo em Inglês | WPRIM | ID: wpr-12170
ABSTRACT

BACKGROUND:

Hair and nails are known to be related in their origin and anatomical structures, and they are similar in their structure and growth pattern. Nail changes were first reported to be associated with alopecia areata (AA) in 1898. One of the clinical features of AA is nail abnormalities, and these are found in 7% to 66% of patients with AA.

OBJECTIVE:

We evaluated the frequency, clinical presentation, and associated factors of nail changes in patients with AA.

METHODS:

A prospective study of 121 patients with AA was performed. The diagnosis of AA was made on clinical grounds. Patients' medical history was obtained, and thorough examinations were performed. Patients with other diseases associated with nail changes were all excluded from the study. The association between the clinical features of patients with AA and the prevalence of nail changes was evaluated using logistic regression analysis.

RESULTS:

Of the 121 patients, 40 (33%) presented with nail changes. In multivariable analysis, younger age (compared with ≥19 years old; odds ratio [OR] 3.663, 95% confidence interval [CI] 1.094~12.346, p=0.035), chronicity (disease duration ≥2 years; OR 2.852, 95% CI 1.230~6.613, p=0.015), and disease subtype (alopecia totalis and alopecia universalis); OR 5.846, 95% CI 1.078~31.717, p=0.041) were identified as independent factors associated with nail changes in patients with AA. Among the nail abnormalities identified, nail pitting was the most common, observed in 20 patients (50%). Trachyonychia was present in 7 patients (16%), leukonychia in 7 (16%), and Beau line in 5 (11%). Other changes were also observed, including melanonychia, onycholysis, absence of lunula, and onychoschizia.

CONCLUSION:

In conclusion, younger age, chronicity, and disease subtype (alopecia totalis and alopecia universalis) were shown to be independent relevant indicators of the nail changes in patients with AA.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Modelos Logísticos / Razão de Chances / Prevalência / Estudos Prospectivos / Diagnóstico / Alopecia / Alopecia em Áreas / Onicólise / Cabelo / Unhas Malformadas Tipo de estudo: Estudo diagnóstico / Estudo de etiologia / Estudo observacional / Estudo de prevalência / Estudo prognóstico / Fatores de risco Limite: Humanos Idioma: Inglês Revista: Korean Journal of Dermatology Ano de publicação: 2016 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Modelos Logísticos / Razão de Chances / Prevalência / Estudos Prospectivos / Diagnóstico / Alopecia / Alopecia em Áreas / Onicólise / Cabelo / Unhas Malformadas Tipo de estudo: Estudo diagnóstico / Estudo de etiologia / Estudo observacional / Estudo de prevalência / Estudo prognóstico / Fatores de risco Limite: Humanos Idioma: Inglês Revista: Korean Journal of Dermatology Ano de publicação: 2016 Tipo de documento: Artigo