A case of hypophosphatemic osteomalacia associated with low-dose adefovir dipivoxil treatment / 대한내과학회지
Korean Journal of Medicine
;
: 261-265, 2010.
Artigo
em Coreano
| WPRIM
| ID: wpr-121796
ABSTRACT
Adefovir dipivoxil (ADV) effectively inhibits lamivudine-resistant hepatitis B virus replication. Hypophosphatemia and elevated serum creatinine are ADV-related nephrotoxicity caused by high-dose ADV. Hypophosphatemic osteomalacia is very rare and is induced by low-dose ADV. A 61-year-old man suffering from chronic hepatitis B manifested with generalized myalgia and bone pain, especially in both ankles and knees. He had been administered ADV for 56 months, since lamivudine-resistant HBV was detected. He developed severe hypophosphatemia and elevated serum alkaline phosphatase levels with a high bone fraction. Bone densitometry and a whole-body bone scan revealed osteoporosis and multiple hot uptake lesions. Blood chemistry and clinical symptoms improved after discontinuing the ADV.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Osteomalacia
/
Osteoporose
/
Estresse Psicológico
/
Adenina
/
Vírus da Hepatite B
/
Hipofosfatemia
/
Hepatite B Crônica
/
Creatinina
/
Densitometria
/
Fosfatase Alcalina
Limite:
Animais
/
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Medicine
Ano de publicação:
2010
Tipo de documento:
Artigo
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