Report of 3 Cases of Chronic Myelogenous Leukemia with Thrombocythemic Onset / 대한진단검사의학회지
The Korean Journal of Laboratory Medicine
;
: 159-162, 2002.
Artigo
em Coreano
| WPRIM
| ID: wpr-121987
ABSTRACT
BACKGROUND:
Differential diagnosis may be difficult between essential thrombocythemia (ET) and chronic myelogenous leukemia (CML) with marked thrombocytosis, mild leukocytosis, and a few immature myeloid cells in peripheral blood at onset. The aim of the present study was to analyze clinical, hematologic, and molecular features of patients with CML, mimicking ET.METHODS:
Among patients from Ewha and Gachon Gil Medical Center between January 1990 and June 2001, our study group included 3 patients with Ph-positive CML with marked thrombocy-tosis (>600 X 10(9)/L) and mild leukocytosis (<20 X 10(9)/L) and 12 patients of the typical ET as a con-trol group.RESULTS:
Peripheral blood basophilia (4 - 12%) and a few immature granulocytes (1 - 9%) were the characteristic features of CML with thrombocythemic onset, compared with the typical ET. There was no evidence of bone marrow eosinophilia, basophilia, or fibrosis in CML with thrombocythemic onset.CONCLUSIONS:
Our study suggests that peripheral basophilia as well as the positivity of Ph chromo-somes or bcr/abl gene rearrangement can be a clue to diagnosis of CML.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Trombocitose
/
Medula Óssea
/
Fibrose
/
Rearranjo Gênico
/
Leucemia Mielogênica Crônica BCR-ABL Positiva
/
Células Mieloides
/
Diagnóstico
/
Diagnóstico Diferencial
/
Eosinofilia
/
Granulócitos
Tipo de estudo:
Estudo diagnóstico
Limite:
Humanos
Idioma:
Coreano
Revista:
The Korean Journal of Laboratory Medicine
Ano de publicação:
2002
Tipo de documento:
Artigo
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