Pathophysiological Role of Neuroinflammation in Neurodegenerative Diseases and Psychiatric Disorders / 대한배뇨장애요실금학회지
International Neurourology Journal
;
: S2-S7, 2016.
Artigo
em Inglês
| WPRIM
| ID: wpr-122242
ABSTRACT
Brain diseases and disorders such as Alzheimer disease, Parkinson disease, depression, schizophrenia, autism, and addiction lead to reduced quality of daily life through abnormal thoughts, perceptions, emotional states, and behavior. While the underlying mechanisms remain poorly understood, human and animal studies have supported a role of neuroinflammation in the etiology of these diseases. In the central nervous system, an increased inflammatory response is capable of activating microglial cells, leading to the release of pro-inflammatory cytokines including interleukin (IL)-1β, IL-6, and tumor necrosis factor-α. In turn, the pro-inflammatory cytokines aggravate and propagate neuroinflammation, degenerating healthy neurons and impairing brain functions. Therefore, activated microglia may play a key role in neuroinflammatory processes contributing to the pathogenesis of psychiatric disorders and neurodegeneration.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Doença de Parkinson
/
Esquizofrenia
/
Transtorno Autístico
/
Encéfalo
/
Encefalopatias
/
Sistema Nervoso Central
/
Citocinas
/
Interleucinas
/
Interleucina-6
/
Microglia
Limite:
Animais
/
Humanos
Idioma:
Inglês
Revista:
International Neurourology Journal
Ano de publicação:
2016
Tipo de documento:
Artigo
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