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Systemic LPS administration induces brain inflammation but not dopaminergic neuronal death in the substantia nigra
Experimental & Molecular Medicine ; : 823-832, 2010.
Artigo em Inglês | WPRIM | ID: wpr-122576
ABSTRACT
It has been suggested that brain inflammation is important in aggravation of brain damage and/or that inflammation causes neurodegenerative diseases including Parkinson's disease (PD). Recently, systemic inflammation has also emerged as a risk factor for PD. In the present study, we evaluated how systemic inflammation induced by intravenous (iv) lipopolysaccharides (LPS) injection affected brain inflammation and neuronal damage in the rat. Interestingly, almost all brain inflammatory responses, including morphological activation of microglia, neutrophil infiltration, and mRNA/protein expression of inflammatory mediators, appeared within 4-8 h, and subsided within 1-3 days, in the substantia nigra (SN), where dopaminergic neurons are located. More importantly, however, dopaminergic neuronal loss was not detectable for up to 8 d after iv LPS injection. Together, these results indicate that acute induction of systemic inflammation causes brain inflammation, but this is not sufficiently toxic to induce neuronal injury.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Substância Negra / Lipopolissacarídeos / Astrócitos / Morte Celular / Ratos Sprague-Dawley / Microglia / Infiltração de Neutrófilos / Encefalite / Injeções Intravenosas Tipo de estudo: Fatores de risco Limite: Animais Idioma: Inglês Revista: Experimental & Molecular Medicine Ano de publicação: 2010 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Substância Negra / Lipopolissacarídeos / Astrócitos / Morte Celular / Ratos Sprague-Dawley / Microglia / Infiltração de Neutrófilos / Encefalite / Injeções Intravenosas Tipo de estudo: Fatores de risco Limite: Animais Idioma: Inglês Revista: Experimental & Molecular Medicine Ano de publicação: 2010 Tipo de documento: Artigo