Role of CD4(+)CD25(high+)FOXP3(+) Regulatory T Cells in Psoriasis
Annals of Dermatology
; : 397-403, 2010.
Article
em En
| WPRIM
| ID: wpr-122632
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND: CD4(+)CD25(high+)regulatory T cells (Tregs) are considered to be of vital importance for maintaining immunologic self-tolerance and preventing autoimmune diseases. These cells have been found to be deficient in skin lesions and in the peripheral blood of patients with psoriasis. OBJECTIVE: To investigate the role of Tregs in the pathogenesis of psoriasis and to evaluate the changes in Tregs in relation to the severity and the clinical course of psoriasis. METHODS: Immunohistochemistry (CD3, 4, 8, 79 and FOXP3) was performed in 22 psoriatic patients compared to 5 normal controls. Flow cytometry (CD3, 4, 8, 25 and FOXP3) was performed in 18 psoriatic patients and 8 normal volunteers and reverse transcriptase polymerase chain reaction (foxp3 mRNA) was performed in 8 psoriasis patients. RESULTS: An increase in the FOXP3(+) cell fraction was detected in the lesional psoriatic skin irrespective of the severity of psoriasis as compared with the normal skin. However, a decrease in FOXP3(+) cells was observed in the samples obtained from psoriasis of 'acute course'. FOXP3(+) Treg populations in the blood of the 'acute course' psoriasis was not different compared to that of 'chronic course' psoriasis and normal controls. CONCLUSION: The deficiency of FOXP3(+) Tregs in the lesional psoriatic skin might be responsible for the exacerbation of psoriasis.
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Índice:
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Assunto principal:
Psoríase
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Pele
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Doenças Autoimunes
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Imuno-Histoquímica
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Linfócitos T
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Linfócitos T Reguladores
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Reação em Cadeia da Polimerase Via Transcriptase Reversa
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Citometria de Fluxo
Limite:
Humans
Idioma:
En
Revista:
Annals of Dermatology
Ano de publicação:
2010
Tipo de documento:
Article