Topical Hypopigmenting Agents for Pigmentary Disorders and Their Mechanisms of Action
Annals of Dermatology
;
: 1-6, 2012.
Artigo
em Inglês
| WPRIM
| ID: wpr-122686
ABSTRACT
Melanin is produced in melanocytes and stored in melanosomes. In spite of its beneficial sun-protective effect, abnormal accumulation of melanin results in esthetic problems. Hydroquinone, competing with tyrosine, is a major ingredient in topical pharmacological agents. However, frequent adverse reactions are amongst its major limitation. To solve this problem, several alternatives such as arbutin, kojic acid, aloesin, and 4-n-butyl resorcinol have been developed. Herein, we classify hypopigmenting agents according to their mechanism of action; a) regulation of enzyme, which is subdivided into three categories, i) regulation of transcription and maturation of tyrosinase, ii) inhibition of tyrosinase activity, and iii) post-transcriptional control of tyrosinase; b) inhibition of melanosome transfer, and c) additional mechanisms such as regulation of the melanocyte environment and antioxidant agents.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Arbutina
/
Pironas
/
Resorcinóis
/
Tirosina
/
Cromonas
/
Monofenol Mono-Oxigenase
/
Hipopigmentação
/
Melanossomas
/
Glucosídeos
/
Hidroquinonas
Idioma:
Inglês
Revista:
Annals of Dermatology
Ano de publicação:
2012
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS