Atopic dermatitis and skin barrier dysfunction
Allergy, Asthma & Respiratory Disease
;
: 20-28, 2013.
Artigo
em Coreano
| WPRIM
| ID: wpr-122736
ABSTRACT
Atopic dermatitis is a chronic relapsing eczematous dermatosis, which usually starts in childhood, and various causes are intricately associated with the development of the disease. Recently, various abnormalities in barrier function have been identified as the cause of atopic dermatitis. Loss-of-function mutation of filaggrin, a significant constituent of skin barrier, has been revealed as a cause for atopic dermatitis, and factors like enhanced protease activity, and decreased synthesis of the lipid lamellae especially ceramides also plays an important role in barrier dysfunction. Not only these genetic causes but also environmental factors are associated in barrier dysfunction, such as soap or detergents which increases skin pH, or proteases of dust mites or cockroaches which enhances epidermal barrier breakdown. Lately, skin barrier dysfunction is also thought to play an important role in the early stage of other allergic diseases such as asthma. Therefore, comprehension of the function of skin barrier can provide help in understanding various allergic diseases.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Peptídeo Hidrolases
/
Asma
/
Pele
/
Dermatopatias
/
Sabões
/
Ceramidas
/
Baratas
/
Compreensão
/
Dermatite Atópica
/
Detergentes
Tipo de estudo:
Estudo prognóstico
Idioma:
Coreano
Revista:
Allergy, Asthma & Respiratory Disease
Ano de publicação:
2013
Tipo de documento:
Artigo
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