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Gastric stem cells and gastric cancer stem cells / 대한해부학회지
Anatomy & Cell Biology ; : 8-18, 2013.
Artigo em Inglês | WPRIM | ID: wpr-122748
ABSTRACT
The gastric epithelium is continuously regenerated by gastric stem cells, which give rise to various kinds of daughter cells, including parietal cells, chief cells, surface mucous cells, mucous neck cells, and enteroendocrine cells. The self-renewal and differentiation of gastric stem cells need delicate regulation to maintain the normal physiology of the stomach. Recently, it was hypothesized that cancer stem cells drive the cancer growth and metastasis. In contrast to conventional clonal evolution hypothesis, only cancer stem cells can initiate tumor formation, self-renew, and differentiate into various kinds of daughter cells. Because gastric cancer can originate from gastric stem cells and their self-renewal mechanism can be used by gastric cancer stem cells, we review here how critical signaling pathways, including hedgehog, Wnt, Notch, epidermal growth factor, and bone morphogenetic protein signaling, may regulate the self-renewal and differentiation of gastric stem cells and gastric cancer stem cells. In addition, the precancerous change of the gastric epithelium and the status of isolating gastric cancer stem cells from patients are reviewed.
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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Células-Tronco / Estômago / Neoplasias Gástricas / Células-Tronco Neoplásicas / Núcleo Familiar / Diferenciação Celular / Proteínas Morfogenéticas Ósseas / Células Enteroendócrinas / Fator de Crescimento Epidérmico / Epitélio Limite: Humanos Idioma: Inglês Revista: Anatomy & Cell Biology Ano de publicação: 2013 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Células-Tronco / Estômago / Neoplasias Gástricas / Células-Tronco Neoplásicas / Núcleo Familiar / Diferenciação Celular / Proteínas Morfogenéticas Ósseas / Células Enteroendócrinas / Fator de Crescimento Epidérmico / Epitélio Limite: Humanos Idioma: Inglês Revista: Anatomy & Cell Biology Ano de publicação: 2013 Tipo de documento: Artigo