The Effects of Recombinant IGF-I on Function and Nitric Oxide Synthase Activity of Kidney during Compensatory Hypertrophy / 대한비뇨기과학회지
Korean Journal of Urology
;
: 1251-1256, 1999.
Artigo
em Coreano
| WPRIM
| ID: wpr-12276
ABSTRACT
PURPOSE:
Among renotropic agents, a growth hormone(GH) independent insulin-like growth factor I(IGF-I) improves renal function without inducing glomerulosclerosis and its potential for treating renal disease is increasing. To elucidate the effect of externally administered IGF-I toward enhancing renal function, the change in renal function and renal nitric oxide synthase(NOS) activity were investigated in the presence of the GH-IGF-I axis. MATERIALS ANDMETHODS:
100?150g Sprague-Dawley male rats were classified four groups according to experimental methods. The left kidney were removed in the rats of UNx group(uninephrectomy) and UNx+IGF-I group(IGF-I treated after uninephrectomy), and sham operation were done in the other rats of control group and Sham+IGF-I group(IGF-I treated after sham operation). The UNx+IGF-I group and Sham+IGF-I group were treated with 300microgram of recombinant IGF-I(rhIGF-I) daily for 5days after operation. The NOS activity were determined in the contralateral kidney tissues and the glomerular filtration rate(GFR) and effective renal plasma flow(ERPF) were determined in the serum.RESULTS:
The GFR, ERPF and NOS activity significantly increased compared to control after uninephrectomy(p<0.05). The GFR, ERPF and NOS activity were significantly different between UNx+IGF-I group and UNx group(p<0.05), but there was no significant difference between Sham+IGF-I group and Sham group after the administration of rhIGF-I.CONCLUSIONS:
Externally administered rhIGF-I increases GFR and ERPF via increasing NOS activity. We suggest that it is especially effective in improving the renal function of damaged kidneys.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Plasma
/
Vértebra Cervical Áxis
/
Fator de Crescimento Insulin-Like I
/
Ratos Sprague-Dawley
/
Fluxo Plasmático Renal Efetivo
/
Óxido Nítrico Sintase
/
Filtração
/
Hipertrofia
/
Rim
/
Óxido Nítrico
Limite:
Animais
/
Humanos
/
Masculino
Idioma:
Coreano
Revista:
Korean Journal of Urology
Ano de publicação:
1999
Tipo de documento:
Artigo
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