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Proton Magnetic Resonance Spectroscopic Changes of the Primary Motor Cortex and Supplementary Motor Area in Hemiparetic Patients with Corticospinal Tract Injury due to Deep Intracerebral Hematoma
Journal of Korean Medical Science ; : 744-749, 2004.
Artigo em Inglês | WPRIM | ID: wpr-123118
ABSTRACT
This study was conducted to investigate the metabolic changes in the motor and motor association cortices following axonal injury in the internal capsule that was caused by deep intracerebral hematoma. Using proton magnetic resonance spectroscopy (1H MRS), the authors studied the primary motor cortices (M-1) and sup-plementary motor areas (SMA) of 9 hemiparetic patients with documentable hemi-paresis of varying severity, and we studied 10 normal volunteers as controls. To measure the M-1 and SMA biochemical changes, 4 separate single volumes of inter-est(VOIs) were located bilaterally in the affected and unaffected hemisphere (AH and UH).1H MRS provided a neuronal and axonal viability index by measuring levels of N-acetylaspartate (NAA) and creatine/phosphocreatine (Cr). The M-1/SMA NAA/Cr ratios of the AH and UH in patients, and the AH and normal volunteers were com-pared. The NAA/Cr ratios of the M-1 and SMA in AH, and the SMA in UH were sig-nificantly lower than those of normal volunteers. These 1H MRS findings indicate that axonal injury in the descending motor pathway at the level of internal capsule could induce metabolic changes in the higher centers of the motor pathway.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Paresia / Fosfocreatina / Prótons / Tratos Piramidais / Espectroscopia de Ressonância Magnética / Ácido Aspártico / Creatina / Hemorragia dos Gânglios da Base / Córtex Motor Limite: Adulto / Idoso / Aged80 / Feminino / Humanos / Masculino Idioma: Inglês Revista: Journal of Korean Medical Science Ano de publicação: 2004 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Paresia / Fosfocreatina / Prótons / Tratos Piramidais / Espectroscopia de Ressonância Magnética / Ácido Aspártico / Creatina / Hemorragia dos Gânglios da Base / Córtex Motor Limite: Adulto / Idoso / Aged80 / Feminino / Humanos / Masculino Idioma: Inglês Revista: Journal of Korean Medical Science Ano de publicação: 2004 Tipo de documento: Artigo