Oxygen free Radical Reactions by Various Partial Pressure of Oxygen in Rats intoxicated with Carbon Monoxide
Korean Journal of Aerospace and Environmental Medicine
;
: 48-57, 1998.
Artigo
em Coreano
| WPRIM
| ID: wpr-123378
ABSTRACT
Experiments, using CO intoxicated male Sprague-Dawley rats, were carried out (1) to see the change of the oxygen tree radical reaction according to partial pressure of oxygen, and (2) to assess the effectiveness of superoxide dismutase (SOD) activity, malondialdehyde (MDA), and ethane as a parameter of the reaction. Ethane was measured in exhaled breath anti SOD activity and MDA In brain tissue. Experimental group consist of (1) Control group (=breathing with air[ambient air]), (2) HBO group (=exposed to hyperbaric oxygen(HBO, 3ATA, l00%] after all breath), (3) CO-Air group (=exposed to CO [3,970 ppm] after air breath followed by air breath), (4) CO-HBO group (=exposed to CO after air breath followed by HBO treatment), and (5) CO group (=exposed to CO after air breath, only for SOD activity & MDA measuring). Amount of ethane exhaled during 30 minutes of HBO treatment after GO exposure was significantly greater than those of all the other groups (p-value= .002) , suggesting more oxygen free radical reaction is taken place in CO intoxicated rats treated with higher partial pressure of oxygen. The long-term follow-up studies are required to differentiate the adverse effects of HBO treatment from the sequelae of CO poisoning itself, and to develop the preventive measures for the adverse effect of HBO treatment. And there was no significnat difference among the five groups in SOD activity and MDA measuring (p-value>.05). This result may be accounted for the rapid recovery of SOD activity and the metabolic degradation and excretion of MDA in a short time. In conclusion, measurement of ethane in exhaled breath is more effective than those of SOD activity and MDA as a parameter to assess the oxygen free radical reaction produced by HBO treatment for CO poisoned rats as a whole
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Oxigênio
/
Pressão Parcial
/
Intoxicação
/
Superóxido Dismutase
/
Encéfalo
/
Carbono
/
Monóxido de Carbono
/
Seguimentos
/
Ratos Sprague-Dawley
/
Etano
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
Limite:
Animais
/
Humanos
/
Masculino
Idioma:
Coreano
Revista:
Korean Journal of Aerospace and Environmental Medicine
Ano de publicação:
1998
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS