Synchronous and metachronous malignancy in endometrial cancer patients treated in a tertiary care center of Thailand / 부인종양
Journal of Gynecologic Oncology
;
: 293-302, 2015.
Artigo
em Inglês
| WPRIM
| ID: wpr-123437
ABSTRACT
OBJECTIVE:
To evaluate the prevalence and features of non-endometrial cancers in Thai endometrial cancer (EC) patients.METHODS:
EC patients treated in our institution were identified and the following data were collected age, EC stage, histopathology, adjuvant therapy, other cancers, living status, and cause of death.RESULTS:
The mean age of the 344 patients was 56.8+/-10.8 years. Fifty (14.5%) had other synchronous and metachronous cancers. Mean ages of the patients with or without other cancers were not significantly different, 55.7+/-10.04 years versus 57.1+/-11.0 years, respectively (p=0.358). History of any cancer in the family and tumor in the lower uterine segment were more frequent among the patients with other cancers (6.0% vs. 1.7%, p=0.095; 12.0% vs. 1.0%, p or =2 other cancers. Ovarian, breast, and colon were the three most common other cancers. After a median follow-up of 57.1 months, 18.3% of patients had died 30.0% of patients with other cancers and 16.3% of those without other cancers. The corresponding EC deaths were 14.0% and 11.2%. The 5-year overall survival was significantly lower in patients who had other cancers 79.3% (95% confidence interval [CI], 68.3 to 90.3) vs. 86.0% (95% CI, 81.7 to 90.3) than in those without (p=0.023). However, the corresponding disease-specific survival was not significantly different 85.1% (95% CI, 75.5 to 94.7) compared with 89.0% (95% CI, 85.1 to 92.9), respectively (p=0.514).CONCLUSION:
Thai EC patients had a high incidence of other cancers. Overall survival of EC patients who had other cancers was worse than those without, while disease-specific survival was not significantly different.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Tailândia
/
Neoplasias da Mama
/
Segunda Neoplasia Primária
/
Neoplasias do Endométrio
/
Quimioterapia Adjuvante
/
Neoplasias do Colo
/
Radioterapia Adjuvante
/
Intervalo Livre de Doença
/
Estimativa de Kaplan-Meier
/
Centros de Atenção Terciária
Tipo de estudo:
Estudo prognóstico
Limite:
Feminino
/
Humanos
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Journal of Gynecologic Oncology
Ano de publicação:
2015
Tipo de documento:
Artigo
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