Analysis of C(-634)G polymorphism in the promotor region of the vascular endothelial growth factor gene in Korean women with endometriosis / 대한산부인과학회지
Korean Journal of Obstetrics and Gynecology
;
: 119-125, 2005.
Artigo
em Coreano
| WPRIM
| ID: wpr-123815
ABSTRACT
OBJECTIVE:
This study was designed to investigate the association between C(-634)G polymorphism in the promotor region of vascualr endothelial growth factor (VEGF) and endometriosis.METHODS:
The genomic DNA was extracted from 100 patients with surgically confirmed endometriosis and 100 control group from July 2003 to June 2004. Following extraction of genomic DNA, genotyping of C(-634)G polymorphism of VEGF gene was performed by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP).RESULTS:
There was no significant difference in the frequency of CC genotype between the patients with endometriosis (21%) and the control group (19%). No significant difference in the frequency of allele of -634C was noted between the two groups (43.5% vs 44%), either.CONCLUSION:
The C(-634)G polymorphism in the promotor region of VEGF gene is not associated with susceptibility to endometriosis in Korean women.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Polimorfismo de Fragmento de Restrição
/
DNA
/
Reação em Cadeia da Polimerase
/
Fatores de Crescimento Endotelial
/
Regiões Promotoras Genéticas
/
Fator A de Crescimento do Endotélio Vascular
/
Endometriose
/
Alelos
/
Genótipo
Limite:
Feminino
/
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Obstetrics and Gynecology
Ano de publicação:
2005
Tipo de documento:
Artigo
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