The Effect of Low-dose Ketamine on Post-caesarean Delivery Analgesia after Spinal Anesthesia
The Korean Journal of Pain
;
: 270-276, 2013.
Artigo
em Inglês
| WPRIM
| ID: wpr-12385
ABSTRACT
BACKGROUND:
Ketamine, an N-methyl-D-aspartate receptor antagonist, might play a role in postoperative analgesia, but its effect on postoperative pain after caesarean section varies with study design. We investigated whether the preemptive administration of low-dose intravenous ketamine decreases postoperative opioid requirement and postoperative pain in parturients receiving intravenous fentanyl with patient-controlled analgesia (PCA) following caesarean section.METHODS:
Spinal anesthesia was performed in 40 parturients scheduled for elective caesarean section. Patients in the ketamine group received a 0.5 mg/kg ketamine bolus intravenously followed by 0.25 mg/kg/h continuous infusion during the operation. The control group received the same volume of normal saline. Immediately after surgery, the patients were connected to a PCA device set to deliver 25-microg fentanyl as an intravenous bolus with a 15-min lockout interval and no continuous dose. Postoperative pain was assessed using the cumulative dose of fentanyl and visual analog scale (VAS) scores at 2, 6, 24, and 48 h postoperatively.RESULTS:
Significantly less fentanyl was used in the ketamine group 2 h after surgery (P = 0.033), but the difference was not significant at 6, 12, and 24 h postoperatively. No significant differences were observed between the VAS scores of the two groups at 2, 6, 12, and 24 h postoperatively.CONCLUSIONS:
Intraoperative low-dose ketamine did not have a preemptive analgesic effect and was not effective as an adjuvant to decrease opioid requirement or postoperative pain score in parturients receiving intravenous PCA with fentanyl after caesarean section.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Dor Pós-Operatória
/
Anafilaxia Cutânea Passiva
/
Cesárea
/
Fentanila
/
Analgesia Controlada pelo Paciente
/
N-Metilaspartato
/
Analgesia
/
Ketamina
/
Raquianestesia
Limite:
Feminino
/
Humanos
/
Gravidez
Idioma:
Inglês
Revista:
The Korean Journal of Pain
Ano de publicação:
2013
Tipo de documento:
Artigo
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