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Sentinel Lymph Node Biopsy in Patients with Clinically Negative Lymph Node After Neoadjuvant Chemotherapy / 한국유방암학회지
Journal of Breast Cancer ; : 254-257, 2007.
Artigo em Coreano | WPRIM | ID: wpr-123866
ABSTRACT

PURPOSE:

We wanted to evaluate the accuracy of sentinel lymph node biopsy (SLNB) in patients with clinically negative lymph node after neoadjuvant chemotherapy.

METHODS:

Fifty-nine women underwent 4 cycles of neoadjuvant chemotherapy with epirubicin (75 mg/m2) plus docetaxel (75 mg/m2), or with doxorubicin (50 mg/m2), cyclophosphamide (600 mg/m2) and 5-fluorouracil (500 mg/m2) for their primary breast cancer. Their median age was 41 yr (range 29-62) and all the tumors were larger than 3 cm in maximum diameter. SLNB was performed 3 min after periareolar injection of 1% isosulfan blue dye. All the patients underwent lymph node dissection at the level 1 and 2 axillary areas irrespective of their nodal status.

RESULTS:

A clinical response after neoadjuvant chemotherapy was observed in 46 patients (88%) and 11 (18.7%) patients had a complete pathologic response. Thirty-five patients (62.7%) underwent breast conserving surgery. The sentinel lymph node was identified in 96.6% and the median number of sentinel nodes was 3 (range 1-6). The median number of dissected nodes was 14 (range 11-47). Metastasis to the lymph node was observed in 56% of the patients. The sentinel lymph node was the only metastatic node in 12 patients. Three patients with a negative sentinel lymph node were confirmed to have metastasis to non-sentinel nodes after the final histologic examination (false negative rate 9.1%). The overall accuracy of SLNB was 94.7%.

CONCLUSION:

SLNB after neoadjuvant chemotherapy was a safe method in patients with clinically negative lymph node.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Neoplasias da Mama / Epirubicina / Mastectomia Segmentar / Doxorrubicina / Biópsia de Linfonodo Sentinela / Ciclofosfamida / Tratamento Farmacológico / Fluoruracila / Excisão de Linfonodo / Linfonodos Limite: Feminino / Humanos Idioma: Coreano Revista: Journal of Breast Cancer Ano de publicação: 2007 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Neoplasias da Mama / Epirubicina / Mastectomia Segmentar / Doxorrubicina / Biópsia de Linfonodo Sentinela / Ciclofosfamida / Tratamento Farmacológico / Fluoruracila / Excisão de Linfonodo / Linfonodos Limite: Feminino / Humanos Idioma: Coreano Revista: Journal of Breast Cancer Ano de publicação: 2007 Tipo de documento: Artigo