Anti-inflammatory Triterpenes and Glyceryl Glycosides from Kandelia candel (L.) Druce
Natural Product Sciences
;
: 150-154, 2015.
Artigo
em Inglês
| WPRIM
| ID: wpr-124633
ABSTRACT
Phytochemical investigation of Kandelia candel resulted in the isolation of six triterpenes (1 - 5) and two glyceryl glycosides (6 and 7) and their structures were determined by comparing the spectroscopic data with those of reported values. In present study, we described the inhibitory effects of fractions and isolated compounds from K. candel on pro-inflammatory cytokines (IL-12 p40, IL-6, and TNF-alpha) production in lipopolysaccharide (LPS) stimulated bone marrow-derived dendritic cells (BMDCs). Results indicated that compounds 3, 6, and 7 showed potent inhibition on IL-6 production (IC50 values at less than 0.5 microM, respectively). Meanwhile, compounds 6 and 7 exhibited strong inhibitory effects on the production of TNF-alpha (IC50 values of 1.7 +/- 0.1 and 5.5 +/- 0.2 microM). Compounds 1 and 3 were also showed the inhibitory effects on IL-12 p40 production (IC50 values of 8.9 +/- 0.4 and 3.3 +/- 0.1 microM, respectively).
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Triterpenos
/
Células Dendríticas
/
Citocinas
/
Interleucina-6
/
Fator de Necrose Tumoral alfa
/
Interleucina-12
/
Rhizophoraceae
/
Glicosídeos
Idioma:
Inglês
Revista:
Natural Product Sciences
Ano de publicação:
2015
Tipo de documento:
Artigo
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