No expression of porcine endogenous retrovirus after pig to monkey xenotransplantation / 한국실험동물학회지
Laboratory Animal Research
; : 90-93, 2014.
Article
em En
| WPRIM
| ID: wpr-124661
Biblioteca responsável:
WPRO
ABSTRACT
This study was performed to investigate the expression of two porcine endogenous retrovirus (PERV) elements, PERV gag and full-length conserved PERV, in blood cells collected periodically from organ-recipient monkeys that underwent pig to non-human primate xenotransplantation. The heart and kidney-respectively acquired from alpha-1,3-galactosyltransferase knockout (GT-KO) pigs that survived for24 and 25 days-were xenografted into cynomolgus monkeys. The two PERV elements expressed in the xenografted GT-KO pig organs were not present in the blood cells of the recipient monkeys. In the present study, we deduced that PERVs are not transmitted during GT-KO pig to monkey xenotransplantation.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Primatas
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Suínos
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Transplante Heterólogo
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Células Sanguíneas
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Haplorrinos
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Retrovirus Endógenos
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Xenoenxertos
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Coração
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Macaca fascicularis
Idioma:
En
Revista:
Laboratory Animal Research
Ano de publicação:
2014
Tipo de documento:
Article