Vitamin D Receptor Gene, Matrix Metalloproteinase 3 Polymorphisms and the Risk of Intervertebral Disc Degeneration Susceptibility: Meta-Analysis

ABSTRACT

Several studies have evaluated the association between vitamin D receptor, matrix metalloproteinase 3 (MMP-3) polymorphisms and the risk of intervertebral disc degeneration susceptibility. The findings were inconsistent. This meta-analysis aimed to systematically assess the association between vitamin D receptor, MMP-3 polymorphisms and the risk of intervertebral disc degeneration susceptibility. A search of various databases was done covering all papers published until December 31th, 2014. Eight, 4, 3 studies were finally included that addressed the risk of intervertebral disc degeneration susceptibility and vitamin D receptor FokI (rs2228570), ApaI (rs7975232), and MMP-3 (rs731236) polymorphisms, respectively. FokI (f vs. F summary odds ratio [OR], 1.13; 95% confidence interval [CI], 0.76–1.69; ff vs. FF OR, 1.02; 95% CI, 0.59–1.77; ff vs. Ff/FF OR, 1.05; 95% CI, 0.70–1.58), ApaI (a vs. A OR, 0.73; 95% CI, 0.45–1.19; aa vs. AA OR, 0.53; 95% CI, 0.22–1.25 p=0.14; aa vs. AA/Aa OR, 0.69; 95% CI, 0.53–0.89) in the vitamin D receptor gene and MMP3 polymorphisms (5A vs. 6A OR, 1.92; 95% CI, 0.77–4.80; 5A5A vs. 6A6A OR, 2.17; 95% CI, 0.75–6.24; 5A5A vs. 5A6A/6A6A OR, 1.58; 95% CI, 0.72–3.44) were not obviously associated with risk of intervertebral disc degeneration susceptibility. FokI, ApaI polymorphisms in the vitamin D receptor gene and MMP-3 polymorphism are not obvious risk factors for intervertebral disc degeneration susceptibility.