A case of Cushing's syndrome in ACTH-secreting mediastinal paraganglioma
The Korean Journal of Internal Medicine
;
: 142-146, 2000.
Artigo
em Inglês
| WPRIM
| ID: wpr-125826
ABSTRACT
Paragangliomas are unusual neuroendocrine cell tumors arising from paraganglia, of which ACTH-secreting cases in the mediastinum are extremely rare. A 51-year-old woman was admitted for generalized edema and weakness which began 5 months ago. Chest X-ray and CT scan revealed a tumor mass in the anterior mediastinum. The plasma cortisol and ACTH levels were very high. Other sources secreting ACTH, except mediastinal mass, were not found. Surgical excision of mediastinal mass and left supraclavicular lymph node was performed. The postoperative microscopic finding and immunohistochemical staining revealed organoid tumor cell nests (zellballen) and S-100 protein positive sustentacular cells which are characteristics of paraganglioma. This was thus a case of Cushing's syndrome resulting from ectopic ACTH production in anterior mediastinal paraganglioma.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Hormônio Adrenocorticotrópico
/
Paraganglioma Extrassuprarrenal
/
Síndrome de Cushing
/
Neoplasias do Mediastino
/
Pessoa de Meia-Idade
Limite:
Feminino
/
Humanos
Idioma:
Inglês
Revista:
The Korean Journal of Internal Medicine
Ano de publicação:
2000
Tipo de documento:
Artigo
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