Mechanism of experimental autoimmune encephalomyelitis in Lewis rats: recent insights from macrophages / 대한해부학회지
Anatomy & Cell Biology
;
: 141-148, 2012.
Artigo
em Inglês
| WPRIM
| ID: wpr-125844
ABSTRACT
Experimental autoimmune encephalomyelitis (EAE) in Lewis rats is an acute monophasic paralytic central nervous system disease, in which most rats spontaneously recover from paralysis. EAE in Lewis rats is induced by encephalitogenic antigens, including myelin basic protein. EAE is mediated by CD4+ Th1 cells, which secrete pro-inflammatory mediators, and spontaneous recovery is mediated by regulatory T cells. Recently, it was established that classically activated macrophages (M1 phenotype) play an important role in the initiation of EAE, while alternatively activated macrophages (M2 phenotype) contribute to spontaneous recovery from rat EAE. This review will summarize the neuroimmunological aspects of active monophasic EAE, which manifests as neuroinflammation followed by neuroimmunomodulation and/or neuroprotection, with a focus on the role of alternatively activated macrophages.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Paralisia
/
Neuroimunomodulação
/
Sistema Nervoso Central
/
Linfócitos T Reguladores
/
Células Th1
/
Proteína Básica da Mielina
/
Encefalomielite Autoimune Experimental
/
Macrófagos
Limite:
Animais
Idioma:
Inglês
Revista:
Anatomy & Cell Biology
Ano de publicação:
2012
Tipo de documento:
Artigo
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