Detection of RUNX1-MECOM Fusion Gene and t(3;21) in a Very Elderly Patient Having Acute Myeloid Leukemia with Myelodysplasia-Related Changes
Annals of Laboratory Medicine
;
: 362-365, 2012.
Artigo
em Inglês
| WPRIM
| ID: wpr-125849
ABSTRACT
An 87-yr-old woman was diagnosed with AML with myelodysplasia-related changes (AML-MRC). The initial complete blood count showed Hb level of 5.9 g/dL, platelet counts of 27x10(9)/L, and white blood cell counts of 85.33x10(9)/L with 55% blasts. Peripheral blood samples were used in all the tests, as bone marrow examination could not be performed because of the patient's extremely advanced age and poor general health condition. Flow cytometric analysis, chromosome analysis, FISH, and reverse transcriptase-PCR (RT-PCR) results indicated AML-MRC resulting from t(3;21) with the RUNX1-MECOM fusion gene. To our knowledge, this is the second most elderly de novo AML patient associated with t(3;21) to be reported.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Translocação Genética
/
Células Sanguíneas
/
Síndromes Mielodisplásicas
/
Cromossomos Humanos Par 3
/
Cromossomos Humanos Par 21
/
Leucemia Mieloide Aguda
/
Proteínas de Fusão Oncogênica
/
Análise de Sequência de DNA
/
Reação em Cadeia da Polimerase Multiplex
/
Cariotipagem
Tipo de estudo:
Estudo diagnóstico
Limite:
Idoso
/
Aged80
/
Feminino
/
Humanos
Idioma:
Inglês
Revista:
Annals of Laboratory Medicine
Ano de publicação:
2012
Tipo de documento:
Artigo
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