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Reference Range of Respiratory Muscle Strength and Its Clinical Application in Amyotrophic Lateral Sclerosis: A Single-Center Study
Journal of Clinical Neurology ; : 361-367, 2016.
Artigo em Inglês | WPRIM | ID: wpr-125900
ABSTRACT
BACKGROUND AND

PURPOSE:

Evaluating respiratory function is important in neuromuscular diseases. This study explored the reference ranges of the maximal inspiratory pressure (MIP), maximal expiratory pressure (MEP), and sniff nasal inspiratory pressure (SNIP) in healthy adults, and applied them to amyotrophic lateral sclerosis (ALS) patients.

METHODS:

MIP, MEP, and SNIP were measured in 67 healthy volunteers aged from 21 to 82 years. Reference ranges were evaluated by multivariate regression analysis using the generalized additive modeling of location, scale, and shape method. Thirty-six ALS patients were reviewed retrospectively, and abnormal values of MIP, MEP, and SNIP were determined according to the reference ranges.

RESULTS:

MIP, MEP, and SNIP were abnormal in 57.1%, 51.4%, and 25.7% of the ALS patients, respectively. MIP and SNIP were significantly correlated with the degree of restrictive pattern and respiratory symptoms. The ALS Functional Rating Scale-Revised score was correlated with SNIP.

CONCLUSIONS:

This study has provided the reference range of respiratory muscle strength in healthy adults. This range is suitable for evaluating respiratory function in ALS patients.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Valores de Referência / Músculos Respiratórios / Estudos Retrospectivos / Voluntários Saudáveis / Esclerose Lateral Amiotrófica / Métodos / Doenças Neuromusculares Tipo de estudo: Estudo observacional / Estudo prognóstico Limite: Adulto / Humanos Idioma: Inglês Revista: Journal of Clinical Neurology Ano de publicação: 2016 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Valores de Referência / Músculos Respiratórios / Estudos Retrospectivos / Voluntários Saudáveis / Esclerose Lateral Amiotrófica / Métodos / Doenças Neuromusculares Tipo de estudo: Estudo observacional / Estudo prognóstico Limite: Adulto / Humanos Idioma: Inglês Revista: Journal of Clinical Neurology Ano de publicação: 2016 Tipo de documento: Artigo