A Study of Efflux Pump Genes in Mycobacterium tuberculosis Clinical Isolates / 대한임상미생물학회지
Annals of Clinical Microbiology
;
: 65-68, 2014.
Artigo
em Inglês
| WPRIM
| ID: wpr-12608
ABSTRACT
The efflux pump system has been suggested as an important mechanism in the drug resistance of Mycobacterium tuberculosis (MTB). In this study, molecular analysis of five genes in the efflux pump system of MTB isolates from Korean patients was performed in order to identify appropriate molecular targets. In this study, 35 culture-positive specimens were included. PCR was performed for five efflux genes, mmpL7, efpA, mmr, p55 and tap-like gene. In the 35 clinical isolates, molecular analysis of five kinds of efflux pump genes was performed. Only one clinical isolate showed negative PCR results for all five efflux pump genes. All the rest 34 isolates presented concurrent positive results for the five efflux pump genes. In the near future, gene expression study with quantitative PCR should be performed using these genes.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Resistência a Medicamentos
/
Expressão Gênica
/
Reação em Cadeia da Polimerase
/
Genes MDR
/
Mycobacterium tuberculosis
Limite:
Humanos
Idioma:
Inglês
Revista:
Annals of Clinical Microbiology
Ano de publicação:
2014
Tipo de documento:
Artigo
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