The Effect of Agoraphobia on Oxidative Stress in Panic Disorder
Psychiatry Investigation
; : 317-325, 2013.
Article
em En
| WPRIM
| ID: wpr-126150
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WPRO
ABSTRACT
We aimed to investigate whether agoraphobia (A) in panic disorder (PD) has any effects on oxidative and anti-oxidative parameters. We measured total antioxidant capacity (TAC), paraoxonase (PON), arylesterase (ARE) antioxidant and malondialdehyde (MDA) oxidant levels using blood samples from a total of 31 PD patients with A, 22 PD patients without A and 53 control group subjects. There was a significant difference between the TAC, PON, ARE and MDA levels of the three groups consisting of PD with A, PD without A and the control group. The two-way comparison to clarify the group creating the difference showed that the TAC, PON, and ARE antioxidants were significantly lower in the PD with A group compared to the control group while the MDA oxidant was significantly higher. There was no significant difference between the PD without A and control groups for TAC, PON, ARE and MDA levels. We clearly demonstrated that the oxidative stress and damage to the anti-oxidative mechanism are significantly higher in the PD group with A. These findings suggest that oxidative/anti-oxidative mechanisms may play a more important role on the pathogenesis of PB with A.
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Índice:
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Assunto principal:
Pânico
/
Transtorno de Pânico
/
Estresse Oxidativo
/
Arildialquilfosfatase
/
Agorafobia
/
Malondialdeído
/
Antioxidantes
Limite:
Humans
Idioma:
En
Revista:
Psychiatry Investigation
Ano de publicação:
2013
Tipo de documento:
Article