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Efficacy of Clomiphene Citrate Stimulated Cycle in Poor Responders in inviro Fertilization / 대한불임학회지
Korean Journal of Fertility and Sterility ; : 239-244, 1998.
Artigo em Coreano | WPRIM | ID: wpr-126167
ABSTRACT
The purpose of this study is compare IVF cycle outcome in poor responders between clomiphene citrate (CC) stimulated and controlled ovarian hyperstimulation (COH) protocol. A total of 94 patients responding poorly in previous IVF cycles (estradiol16 mm. In COH group, ovarian stimulation was done using short protocol (GnRH-a/FSH/HMG/hCG). No difference in age or number of transferred embryos was found between CC group and COH group. COH group had significantly (p<0.05) higher mean peak level of E2 (810+/-112 vs 412+/-55 pg/ml) and greater number of retrieved oocytes (3.0+/-0.2 vs 2.0+/-0.2) than CC group. CC group had significantly embryos (1.8+/-0.2) compared with (2.1+/-0.2) in COH group. However, CC group had higher pregnancy rate than COH group per retrieval [26.9% (7/26) vs 6.2% (6/97)], or per transfer [31.8% (7/22) vs 7% (6/86)]. Although cycle cancellation rate in CC group (48.8%) was higher than that of COH group (21.3%), the pregnancy rate per cycle in CC group was still higher (16.3%) than COH group (4.9%). In addition, implantation rate in CC group was 17.5% (7/40), which was significantly p<0.01) higher than 3.9% (7/180) in COH group. These data suggest that oocyte and embryo quality are lower in COH cycles of poor responders than CC cycles. We suggest that clomiphene citrate stimulated IVF cycle may be more efficient than COH IVF cycle in poor responders in terms of lower costs and higher pregnancy performance.
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Oócitos / Indução da Ovulação / Ultrassonografia / Clomifeno / Taxa de Gravidez / Estruturas Embrionárias / Estradiol / Fertilização Tipo de estudo: Estudo diagnóstico Limite: Humanos / Gravidez Idioma: Coreano Revista: Korean Journal of Fertility and Sterility Ano de publicação: 1998 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Oócitos / Indução da Ovulação / Ultrassonografia / Clomifeno / Taxa de Gravidez / Estruturas Embrionárias / Estradiol / Fertilização Tipo de estudo: Estudo diagnóstico Limite: Humanos / Gravidez Idioma: Coreano Revista: Korean Journal of Fertility and Sterility Ano de publicação: 1998 Tipo de documento: Artigo