Primary Histiocytic Sarcoma of the Central Nervous System / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment
;
: 322-328, 2015.
Artigo
em Inglês
| WPRIM
| ID: wpr-126945
ABSTRACT
Histiocytic sarcoma is a type of lymphoma that rarely involves the central nervous system (CNS). Its rarity can easily lead to a misdiagnosis. We describe a patient with primary CNS histocytic sarcoma involving the cerebral hemisphere and spinal cord, who had been initially misdiagnosed as demyelinating disease. Two biopsies were necessary before a correct diagnosis was made. A histologic examination showed bizarre shaped histiocytes with larger nuclei and nuclear atypia. The cells were positive for CD68, CD163, and S-100 protein. As a resection was not feasible due to multifocality, he was treated with highdose methotrexate, but showed no response. As a result, he was switched to high dose cytarabine; but again, showed no response. The patient died 2 months from the start of chemotherapy and 8 months from the onset of symptoms. Since few patients with this condition have been described and histopathology is difficult to diagnose, suspicion of the disease is essential.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Sarcoma
/
Medula Espinal
/
Biópsia
/
Proteínas S100
/
Sistema Nervoso Central
/
Metotrexato
/
Doenças Desmielinizantes
/
Citarabina
/
Diagnóstico
/
Erros de Diagnóstico
Tipo de estudo:
Estudo diagnóstico
Limite:
Humanos
Idioma:
Inglês
Revista:
Cancer Research and Treatment
Ano de publicação:
2015
Tipo de documento:
Artigo
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