A Case of Lambert-Eaton Myasthenic Syndrome with Small-Cell Lung Cancer and Transient Increase in Anti-Acetylcholine-Receptor-Binding Antibody Titer
Journal of Clinical Neurology
;
: 305-307, 2012.
Artigo
em Inglês
| WPRIM
| ID: wpr-12699
ABSTRACT
BACKGROUND:
Lambert-Eaton myasthenic syndrome (LEMS) is a presynaptic neuromuscular junction disorder that is most frequently associated with small-cell lung cancer (SCLC). The titers of antibodies against voltage-gated calcium channels are frequently increased in LEMS, but only rarely is titer of anti-acetylcholine-receptor-binding antibodies (AChR-abs) increased. CASE REPORT A 57-year-old male was admitted to our hospital due to dry mouth and eyes and progressive proximal limb weakness of 2 months duration. The results of a repetitive nerve stimulation test disclosed all criteria for the electrophysiological LEMS pattern, and the patient's AChR-abs titer was 0.587 nmol/L. At a follow-up performed 5 years after successful treatment of SCLC and LEMS, his AChR-abs titer had decreased to 0.001 nmol/L.CONCLUSIONS:
We suggest that this was a case of transient pseudopositivity of AChR-abs in SCLC with LEMS.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Canais de Cálcio
/
Síndrome Miastênica de Lambert-Eaton
/
Seguimentos
/
Doenças da Junção Neuromuscular
/
Extremidades
/
Olho
/
Pulmão
/
Neoplasias Pulmonares
/
Anticorpos
/
Boca
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Limite:
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Journal of Clinical Neurology
Ano de publicação:
2012
Tipo de documento:
Artigo
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