The Role of Nitric Oxide in the Relaxation of Canine Corpus Cavernosum Smooth Muscle / 대한비뇨기과학회지
Korean Journal of Urology
;
: 841-845, 1994.
Artigo
em Coreano
| WPRIM
| ID: wpr-127108
ABSTRACT
Nitric Oxide(NO) has been known to be endothelium-derived relaxing factor in blood vessels, and to be nonadrenergic-noncholinergic(NANC) neurotransmitter involved in the relaxation of corpus cavernosum smooth muscle of man and rabbit. This study was initiated to determine NANC inhibitory neurotransmission in the canine corpus cavernosum. Using organ bath, isometric tension measurements were made in strips of canine corpus cavernosum. Transmural electrical stimulation of corporal tissue strips, in the presence of adrenergic blockade with bretylium and muscarinic receptor blockade with atropine, caused frequency-dependent relaxation. This relaxation was inhibited significantly by nitric oxide synthase inhibitor, N-nitro-L-arginine methyl ester(L-NAME). Our findings suggest that there should be nonadrenergic-noncholinergic neurotransmitter in the canine corpus cavernosum smooth muscle and it could be nitric oxide. Canine erectile tissue might serve as in vitro model for further investigation of corpus cavernosal smooth muscle pathophysiology.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Relaxamento
/
Atropina
/
Banhos
/
Vasos Sanguíneos
/
Receptores Muscarínicos
/
Transmissão Sináptica
/
Neurotransmissores
/
Óxido Nítrico Sintase
/
Fatores Relaxantes Dependentes do Endotélio
/
Estimulação Elétrica
Tipo de estudo:
Estudo prognóstico
Idioma:
Coreano
Revista:
Korean Journal of Urology
Ano de publicação:
1994
Tipo de documento:
Artigo
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