Effects of Sinapic Acid of 4 Vessel Occlusion Model-Induced Ischemia and Cognitive Impairments in the Rat
Clinical Psychopharmacology and Neuroscience
;
: 86-90, 2011.
Artigo
em Inglês
| WPRIM
| ID: wpr-127841
ABSTRACT
OBJECTIVE:
Sinapic acid (SA, Sinapine), small naturally occurring hydroxycinnamic acid, has a GABA(A) receptor agonistic property and free radical scavenging activity. We examined potential neuroprotective effects of sinapic acid (SA) using global cerebral ischemia animal model.METHODS:
MTT assay was performed to determine cytotoxic effects of SA. To examine the neuroprotective effects of SA, SA was administrated for 14 d before 4-vessel occlusion. Also, to determine whether SA prevents cognitive impairment, Morris water maze was performed.RESULTS:
In this study, the efficacy of SA for the prevention of neuronal damage and for the reduction of memory impairment was investigated.CONCLUSION:
The results indicate that SA confers significant neuroprotection especially for ischemic hippocampal neurons.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Isquemia Encefálica
/
Receptores de GABA-A
/
Fármacos Neuroprotetores
/
Aprendizagem em Labirinto
/
Ácidos Cumáricos
/
Glicosaminoglicanos
/
Hipocampo
/
Isquemia
/
Memória
/
Neurônios
Limite:
Animais
Idioma:
Inglês
Revista:
Clinical Psychopharmacology and Neuroscience
Ano de publicação:
2011
Tipo de documento:
Artigo
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